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Breakthrough infections and boosters

The good news is that a complete dose of the currently authorized COVID-19 vaccines remains effective. “All the vaccines work pretty well,” said Jeff Kwong, an infectious diseases epidemiologist at the University of Toronto. “And the vaccines were more protective against the severe outcomes compared to symptomatic infection,” Kwong has shown in a study, not yet peer reviewed, the effectiveness of Pfizer, Moderna, and AstraZeneca vaccines against symptomatic infection, hospitalization, or death between December 2020 and May 2021.Robot Sex Doll

Many studies have shown that Moderna and Pfizer vaccines still protect against Delta, though not as well as against previous variants. Unvaccinated people make up more than 90 percent of confirmed new cases among the states that track case data along with vaccination status.

“[Vaccines] do reduce the risk of serious outcome such as hospitalization quite substantively,” says Aziz Sheikh, a primary care specialist at The University of Edinburgh, Scotland, UK who showed that Delta caused twice as many hospitalizations than the Alpha variant, which caused more severe illness than the original SARS-CoV-2. “Overall, they are working.”Silicone Sex Dolls

The CDC estimates that COVID-19 vaccination reduces the risk of SARS-CoV-2 infection by eight-fold and the risk of getting ill, being hospitalized, or dying by 25-fold.

But inadequate testing nationwide makes it impossible to know the true extent of the spread of Delta and other variants. When there is high transmission of Delta in the community, even fully vaccinated people are vulnerable to so-called “vaccine breakthrough infections,” which the CDC defines as when genetic material or protein from SARS-CoV-2 is detectable in the nasal swab more than 14 days after a person has received the recommended dose of an FDA-authorized COVID-19 vaccine.Furry Sex Doll

Two doses of the AstraZeneca and Pfizer vaccines are estimated to be 60 and 88 percent effective, respectively, against symptomatic disease caused by Delta. The majority of vaccines administered in the U. S. (Moderna and Pfizer) require two shots for maximum protection. These vaccines are much less effective against Delta after just a single jab, says Olivier Schwartz, head of the Virus and Immunity Unit at Institut Pasteur, Paris, who led a study that showed that a single dose of either AstraZeneca and Pfizer vaccines or previous infection barely inhibit Delta variant.

Prompted by the data on the reduced efficacy against new variants such as Delta, Pfizer is seeking authorization of a booster dose of its vaccine. Moderna is also testing an updated mRNA vaccine booster dose. The U.S. Food and Drug Administration (FDA) is expected to finalize a COVID-19 vaccine booster plan soon.